Effect of Cyanide on Some Chlorpromazine Responses

Abstract

Summary

We have shown that chlorpromazine, like compound 48–80 which is a powerful histamine liberator, destroys mast cells in vivo and that cyanide prevents this disruption. Furthermore cyanide also prevents some of the hypothermic effect of chlorpromazine. Consequently, our study may be regarded as further evidence to a possible relationship between mast cell disruption and hypothermia caused by chlorpromazine.