Abstract
Summary
Five normal, male, human subjects have been studied by the classical clearance technics during salt deprivation before and after therapy with the steroid-17-spirolactone, SC 8109. No change in the glomerular filtration rate or effective renal plasma flow could be demonstrated but a definite sodium diuresis and potassium retention occurred in response to the spirolactone. A small increase in free water clearance was seen in 4 of 5 subjects studied. These observations localize the effect of spirolactone to the renal tubule.
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