Prevention of Steroid Induced Ulcers with an Anticholinergic Drug

Abstract

Summary

Ulcers were produced in glandular portion of stomach of fasting rats with δ¹-cortisol (δ¹-COL). When methscopolamine bromide, an anticholinergic, was administered, these steroid induced ulcers were prevented proportionately to dose. Methscopolamine, given alone, increased the amount of visible mucus on mucosal surface. Methscopolamine would protect by counteracting some effects of corticoids on gastric secretion and perhaps also by stimulating mucus formation.