Abstract
Summary
When a single subcutaneous injection of 0.1 μg of estradiol 17-β is administered to immature rats immediately following removal of 60%–70% of liver, fluid imbibition by the uterus is retarded 3–6 hours and at maximum is somewhat less than in normal animals at 6 hours. However, partial hepatectomy does not modify growth response of the uterus to estrogen. There is no significant difference in uterine growth between control and experimental animals from approximately 15th to 30th hour following a single injection of estrogen. Since the effect of partial hepatectomy on fluid imbibition by the uterus is primarily a retardaton, and uterine growth is not changed, it seems doubtful that the liver has important influence on the action of estrogen under these conditions.
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