Abstract
Summary
(1) The effect of infusing an amino acid mixture (protein hydrolysate) on plasma NEFA, venous glucose level, and capillary-venous glucose difference, was studied in 6 healthy volunteer subjects. In every instance, plasma NEFA levels fell precipitously during amino acid infusion, and capillary-venous glucose differences increased concurrently. Similar results were obtained when a single amino acid, L-arginine, was infused in 2 normal subjects. (2) The results suggest that NEFA-lowering effects of parenterally administered amino acids may have been mediated entirely or in part via an induced increase in rate of glucose utilization.
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