Abstract
Summary
When tested for ability to stimulate seminal vesicles and prostates of castrate, immature rats, a series of progestational steroids produced results as follows: 1) None of the compounds has androgenic activity approaching that of standard androgens, methyl-testosterone or testosterone propionate. 2) All compounds tested orally produced some stimulation of the prostate, although it was extremely slight in the case of 17α-acetoxy progesterone and 6α-methyl-17α-acetoxy progesterone. Significant stimulation of seminal vesicles was seen only with 17α-ethinyltestosterone, 17α-ethinyl-19-nortestosterone, and EN. 3) Of compounds tested subcutaneously, only 17α-(2-methallyl)-19-nortestosterone failed to stimulate the seminal vesicle. All compounds produced some stimulation of the prostate, although EN and 17α-(2-methallyl)-19-nortestosterone produced minimal responses.
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