Growth Hormone and Thyroxine

Abstract

Summary

Submaxillary glands of hypophysectomized male albino rats injected with growth hormone and thyroxine, both alone and in combination, were studied histologically and enzymatically. Growth hormone and thyroxine separately were only partially effective in preventing hypophysectomy-induced enzymatic and histologic changes in the submaxillary salivary gland. The 2 hormones when administerd together, however, maintained normal histologic and enzymatic activity. These results are comparable to those previously reported utilizing testosterone and thyroxine in combination. Apparently the stimulatory action of thyroxine upon the submaxillary gland function may be enhanced by simultaneous administration of either testosterone or growth hormone, both of which are deficient in the hypophysectomized animal.