Abstract
Summary
A method based upon potentiation of a subhypnotic dose of hexobarbital has been employed to detect depressant activity of drugs. It is rapid, and gives reproducible results with known CNS depressants. It appears to differentiate depressant drugs from those which prolong the action of a hypnotic dose of hexobarbital by interference with biotransformation mechanisms. It affords a rapid means of detecting depressant activity of drugs not ordinarily classified as central depressants.
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