Abstract
Summary
Seitz filtration of poliomyelitis vaccine pools during formaldehyde-inactivation process was found to lower their immunogenic activity. Monovalent vaccine pools in which filtration through Seitz filter pads during inactivation process was either omitted or replaced by filtration through fritted glass filters, proved to be of high antigenicity both in guinea pigs and in triply negative children. Routine safety tests in tissue culture carried out on such pools were consistently negative. Additional proof of the safety of such pools was provided by absence of live poliovirus from large samples withdrawn as much as 5 days prior to end of inactivation period, and also by use of these vaccines in the field.
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