Abstract
Summary
1) The polarographic method for measuring changes in O2 concentration has been employed for assessing ability of salicylates and related compounds to uncouple phosphorylation. The extent of stimulation of respiration caused by addition of these compounds to rat heart mitochondria oxidizing alpha-ketoglutarate in a phosphate-acceptor deficient system was used as a criterion of uncoupling action. 2) Thiosalicylate was many times more active than salicylate and other salicy late-derivatives tested. Some chemical and physical properties possibly responsible for the uncoupling action of salicylate and certain of its congeners were considered. The in vitro action of salicylates was discussed in relation to their anti-rheumatic activity and cardiovascular effects.
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