Abstract
Summary
1. Incubation of freshly prepared human platelets with a variety of sulfhydryl inhibitors results in increased rate of platelet breakdown. 2. In all cases studied the effects of inhibitors can be decreased in extent by suitable concentrations of SH-containing substances such as cysteine or reduced glutathione. 3. Results obtained suggest a direct relationship between platelet sulfhydryl groups and platelet structure. The possible link of this relationship to platelet metabolism is briefly discussed.
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