Abstract
Summary
1. Small doses of hydrocortisone decrease the amount of hypothermia and increase survival time of adrenalectomized rats given a lethal amount of E. coli lipopoly-saccharide (endotoxin). 2. Using survival time as the criterion of response, the dose response relationships for hydrocortisone in the adrenalectomized rat and for corticotropin in the hypophysectomized rat were determined. When the log of dose was plotted vs. response, the lines were linear in ranges of 10 to 200 μg of hydrocortisone and 0.5 to 4.5 milliunits of corticotropin. The indices of precision were approximately 0.3 and 1.0 for hydrocortisone and corticotropin, respectively. 3. The effect of sex and age of animals and time of administration on response to hydrocortisone were studied.
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