Abstract
Summary
Mucoproteins known to be inhibitors of viral agglutination inhibited agglutination of rabbit erythrocytes by the wax bean hemagglutinin (WBH). Pretreatment of red blood cells with influenza (PR 8) or Newcastle Disease virus reduced susceptibility of such cells to agglutination. The enzymatic release of sialic acid from rabbit serum by a receptor-destroying enzyme prepared from Cl. perfringens was accompanied by a loss in inhibitory activity of serum against WBH agglutination. These and related observations suggest that the site of reaction of WBH with erythrocytes is similar, if not identical, to that of the viral receptor site on the surface of the cell.
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