Abstract
Summary
Evidence has been presented on formation of a pharmacologically active substance from fraction IV-4 of plasma protein by the action of an α-amylase preparation. Formation of the active substance stimulates the isolated guinea pig ileum and produces a pressor response on dog and rabbit blood pressure. It differs from bradykinin since that substance is a vasodilator. The active substance produced by action of α-amylase on fraction IV-4 of plasma protein has been provisionally designated as Substance A. Further studies concerning enzymatic formation as well as purification and characterization of Substance A will be published.
Get full access to this article
View all access options for this article.