Abstract
Summary
Normal rat kidneys and kidneys with a narrowed renal artery have abundant granules in the juxtaglomerular cells and large quantities of extractable renin. On the other hand, kidneys of rats with desoxycorticosterone hypertension and the “untouched' kidney of rats with unilateral renal hypertension (resulting from narrowing of the contralateral renal artery) both have a virtual absence of juxtaglomerular granules as well as absence of extractable renin. There is so little renin in these kidneys that the renal extracts usually produce a depressor response. Thus, there exists a striking correlation between the amount of juxtaglomerular granulation and the amount of extractable renin in a kidney. This does not prove that these granules are composed of renin but the observations are compatible with such a hypothesis.
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