Abstract
Summary
Hexamethonium reduced sensitivity of adrenal medulla to nicotine, but not to potassium. A newly synthesized compound. N-N-diisopropyl-N′-n-butyl-N′-diethylaminoethyl urea (P-275) was similar to hexamethonium in its effects on the adrenal, as well as in its ability to inhibit the cardiovascular depressant effects of vagal stimulation and the acetylcholine stimulation of the isolated atropinized rabbit heart.
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