Aromatic Amines II. Demonstration of 2-amino-1-naphthyl Glucuronides as Metabolite of 2-naphthylamine in Dog Urine. ∗

Abstract

Summary

2-amino-1-naphthyl glucuronide was demonstrated to be a urinary metabolite in dogs fed 2-naphthylamine by identification of the material with the aid of chromatography and enzymatic technics. 3.5–13.3% of ingested dose is excreted in this form when dogs are fed 1 g/day. The possible relation of this glucuronide to bladder cancer is discussed.