Abstract
Summary and conclusion
Introduction of the 14α-hydroxy group into cortisol caused a severe reduction in thymolytic activity when assessed by a test employing the adrenalectomized rat, while similar studies in the mouse indicated a thymolytic activity of the order of cortisol. These studies demonstrate that relative activity of 2 corticoids on the thymolytic test can vary as much as 8-fold depending upon the animal and conditions chosen for the bioassay.
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