Incorporation in vivo of P 32 from Condensed Phosphates

Abstract

Summary

P³² from trimetaphosphate and polymetaphosphate localizes preferentially in bone, particularly in actively growing areas. The metaphosphates are superior to NaH_2- P³²O₄ as a P³² donor to bone, the extent depending upon experimental conditions. In particular, polymetaphosphate has a longer body retention and a higher bone-soft tissue ratio. The equivalent localization of P³² from NaH₂P³²O₄, trimetaphosphate and polymetaphosphate into the nuclei and mitochondria of liver cells is offered as evidence that the metaphosphates are enzymatically broken down to phosphates before incorporation.