Abstract
Summary
Certain Na-salts (chloride, acetate, citrate and lactate) are well tolerated even by rats simultaneously treated with 2α-methyl-9α-chlorocortisol (Me-Cl-COL) or a severe stressor, such as forced restraint. However, these same salts produce massive and sometimes fatal myocardial necroses, in rats exposed to the stress of forced restraint after conditioning with Me-Cl-COL. It appears that during stress the metabolism of certain otherwise innocuous Na-salts and/or steroids is so altered that they acquire severe cardio-toxic properties.
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