Note on the action of tonsillar extract

Abstract

We used the dried powdered tonsil of the calf. When a filtered infusion of two grains of the powdered tonsil was injected into the cat by the jugular vein in divided doses, it produced a great fall of blood-pressure, lasting about a minute, followed by a rise above normal, with a much slower and stronger heart beat. Increase of this dose suddenly arrested the heart. In the same animal it was also a diuretic, increasing the flow of urine twenty times the original amount.