How a route of administration is selected, and what concerns govern the development and execution of techniques for administration of various materials by different routes is an essential component of knowledge for the working toxicologist. More than 26 routes see at least some use in toxicology, each with its own specific concerns, advantages, and disadvantages. Most are infrequently used and poorly understood. The purpose of this communication is to summarize these potential routes and to present an overview of some of the factors that may influence results achieved by the use of different routes of administration.
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