PPG-40 Butyl Ether is the polypropylene glycol ether of butyl alcohol, which is used as a skin and hair conditioning agent in cosmetic products. The oral LD50 for rats, based on a 14-day observation period, was 34.3 ml/kg. No other safety test data were available on PPG-40 Butyl Ether regarding subchronic and chronic toxicity, dermal or eye irritation and sensitization, mutagenicity, carcinogenicity, and teratogenicity. It cannot be concluded that this ingredient is safe for use in cosmetic products until the needed safety data cited in the report have been obtained and evaluated.
References
1.
COSMETIC, TOILETRY AND FRAGRANCE ASSOCIATION (CTFA). (1983). CTFA List of Japanese Cosmetic Ingredients. Washington, DC: The Cosmetic, Toiletry, and Fragrance Association, p. 64.
2.
Estrin, N.F., Crosley, P.A., and Haynes, C.R. (Eds.) (1982). CTFA Cosmetic Ingredient Dictionary, 3rd Edition. Washington, DC: The Cosmetic, Toiletry, and Fragrance Association, p. 229.
3.
FEDERAL REGISTER. (1992). Modifications in voluntary filing of cosmetic product ingredient and cosmetic raw material composition statements. Final rule.57(18):3128–30.
4.
FOOD AND DRUG ADMINISTRATION (FDA). (1981). Product formulation data. Computer printout. Washington, DC: FDA.
5.
FOOD AND DRUG ADMINISTRATION (FDA). (1984). Product formulation data. Computer printout. Washington, DC: FDA.
6.
FOOD AND DRUG ADMINISTRATION (FDA). (1991a). Acute toxicity of related polyoxyalkylene glycols. Submitted by FDA: FOl dated 04/22/91 (6 pp).
7.
FOOD AND DRUG ADMINISTRATION (FDA). (1991b). Frequency of use data. Computer printout. Washington, DC: FDA.
8.
FOOD AND DRUG ADMINISTRATION (FDA). (1992). Product formulation data.
9.
Nikitakis, J.M. (Editor). (1988). CTFA Cosmetic Ingredient Handbook, 1st Edition. Washington, DC: The Cosmetic, Toiletry, and Fragrance Association, p. 320.
