Jojoba Oil is obtained from seeds of the desert shrub, Jojoba (Simmondsia chinensis) and is used in cosmetic products at concentrations ranging from ≥ 0.1% to 25.0%.
The oral LD50 for male rats is greater than 21.5 ml/kg. Results from short-term oral toxicity studies of Jojoba Oil indicated no treatment-related effects. Only slight conjunctival hyperemia was observed in the eyes of rabbits 1 h after the instillation of Jojoba Oil. Reactions had cleared by 24-h post-instillation.
No significant skin irritation reactions were observed in albino guinea pigs patch tested with undiluted Jojoba Oil. In a maximization test, no sensitization reactions were observed in 20 male and female albino marmots patch tested with 10.0% Jojoba alcohol.
A mixture of Jojoba Oil and hydrogenated Jojoba Wax was not mutagenic, with and without activation, in the Ames assay.
A topical oil product containing 0.5% Jojoba Oil and a lip balm product containing 20.0% Jojoba Oil were classified as nonirritants and nonsensitizers to humans. Sensitization reactions to undiluted Jojoba Oil were not observed in a group of 28 patients with no known sensitivities.
On the basis of the available animal and clinical data presented in this report, it is concluded that Jojoba Oil and Jojoba Wax are safe as cosmetic ingredients in the present practices of use and concentration.
References
1.
1. Estrin, N.F., Crosley, P.A., and Haynes, C.R. (1982). CTFA Cosmetic Ingredient Dictionary. Washington, DC: Cosmetic, Toiletry and Fragrance Association, Inc., p. 199.
2.
2. COSMETIC, TOILETRY, and FRAGRANCE ASSOCIATION, (CTFA). (1989). Submission of unpublished data by CTFA. CTFA specification on jojoba oil. Washington, DC: Cosmetic, Toiletry and Fragrance Association, Inc. (1 page).1
3.
3. Hunting, A.L.L. (1983). Encyclopedia of Shampoo Ingredients. Cranford, NJ: Micelle Press, Inc. p. 260.
5. Mckeown, E.C. (1983). Jojoba: A botanical with proven functionality. Cosmet. Toilet.98(June Issue), 81–3.
6.
6. Shani, A. (1983). Jojoba oil and some of its derivatives in cosmetic and health products. Soap, Cosmet., Chem. Spec.59(7), 42, 44.
7.
7. Reinhardt, J.G., and Brown, J.H. (1990). Submission of unpublished data by Jojoba Growers and Processors, Inc. Jojoba Oil and Derivatives—Safety and Applications in Cosmetics. Jojoba Growers and Processors, Inc., Apache Junction, AZ (40 pages).1
8.
8. Brown, J.H. (1984). Jojobutter-51—A primary dermal irritation study in rabbits. Cosmet. Toilet.99 (May Issue), 57–8.
9.
9. Miwa, T.K. (1973). Chemical aspects of jojoba oil. A unique wax from desert shrub Simmondsia californica. Cosmet. Perfum.88 (Jan. Issue), 39–41.
10.
10. Hamm, D.J. (1984). Preparation and evaluation of trialkoxytricarballylate, trialkoxycitrate, trialkoxyglycerylether, jojoba oil, and sucrose polyester as low calorie replacements of edible fats and oils. J. Food Sci.49(2), 419–428.
11.
11. Taguchi, M., and Kunimoto, T. (1977). Toxicity studies on jojoba oil for cosmetic uses. Cosmet. Toilet.19 (September Issue), 53–62.
12.
12. Swern, D. (1982). Bailey's Industrial Oil and Fat Products, Vol. 2, 4th Edition. New York, NY: John Wiley and Sons.
13.
13. Nikitakis, J.M. (1988). CTFA Cosmetic Ingredient Handbook. Washington, DC: The Cosmetic, Toiletry and Fragrance Association, Inc. p. 242.
14.
14. FOOD AND DRUG ADMINISTRATION (FDA). (1989). Cosmetic product formulation data. FDA computer printout.
15.
15. CODE OF FEDERAL REGULATIONS (CFR). (Revised as of April 1, 1984). Title 21 Part 720.4. Voluntary filing of cosmetic product ingredient and cosmetic raw material composition statement. Information requested about cosmetic products. Washington, DC: U.S. Government Printing Office.
16.
16. NIKKO CHEMICALS COMPANY, LTD. (1989). Cross Reference Index: An Index Cross-Referencing the English Names of Cosmetic Ingredients in Japan with CTFA Adopted Names. Tokyo, Japan. Nikko Chemicals Company, Ltd.
18. Scott, M.J., and Scott, M.J., Jr. (1982). Jojoba oil (letter]. J. Am. Acad. Dermatol.6(4), 545.
19.
19. Clarke, J.A., and Yermanos, D.M. (1981). Effects of ingestion of jojoba oil on blood cholesterol levels and lipoprotein patterns in New Zealand white rabbits. Biochem. Biophysics. Res. Commun.102(4), 1409–15.
20.
20. Yaron, A., Benzioni, A., and More, I. (1980). Absorption and distribution of jojoba wax injected subcutaneously into mice. Lipids15(11), 889–94.
21.
21. Wisniak, J. (1977). Jojoba oil and derivatives. Prog. Chem. Fats Other Lipids15(3), 167–218.
22.
22. CTFA. (1985). Submission of unpublished data by CTFA. CIR Safety Data Test Summary Response Form. Acute oral toxicity study on a lip balm product containing 20.0% jojoba oil. No CTFA Code Number (1 page).'
23.
23. Taguchi, M. (no date). Submission of unpublished data by the Jojoba Growers and Processors, Inc. Test results on safety of jobacohol (jojoba alcohol) for cosmetic use. Jojoba Growers and Processors, Inc., Apache Junction, AZ (22 pages).1
24.
24. Yaron, A., Benzioni, A., More, I., Mahler, D., and Meshorer, A. (1982). Physiological toleration of jojoba wax in laboratory animals. J. Soc. Cosmet. Chem.33 (May/June), 141–8.
25.
25. CTFA. (1985). Submission of unpublished data by CTFA. CIR Safety Data Test Summary Response Form. Ocular irritation study on a lip balm product containing 20.0% jojoba oil. No CTFA Code Number (1 page).1
26.
26. CFR. (1982). Title 16 Part 1500.42. Test for eye irritants. Washington, DC: U.S. Government Printing Office.
27.
27. Draize, J.H. (1959). Dermal Toxicity. In: Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics. Austin, TX: The Association of Food and Drug Officials of the U.S., pp. 46–59.
28.
28. CTFA. (1985). Submission of unpublished data by CTFA. CIR Safety Data Test Summary Response Form. Primary skin irritation study on a lip balm product containing 20.0% jojoba oil. No CTFA Code Number (1 page).1
29.
29. Morris, W.E. and Kwan, S.C. (1983). Use of the rabbit ear model in evaluating the comedogenic potential of cosmetic ingredients. J. Soc. Cosmet. Chem.34, 215–225.
30.
30. BIO-TECHNICS LABORATORIES, INC. (1990). Submission of unpublished data by Jojoba Growers and Processors, Inc. Comedogenicity study on Transjojoba-30, a jojoba ester. Jojoba Growers and Processors, Inc., Apache Junction, AZ (3 pages).1
31.
31. BIO-TECHNICS LABORATORIES, INC. (1990). Submission of unpublished data by Jojoba Growers and Processors, Inc. Comedogenicity study on Transjojoba-60, a jojoba ester. Jojoba Growers and Processors, Inc., Apache Junction, AZ (4 pages).1
32.
32. BIO-TECHNICS LABORATORIES, INC. (1990). Submission of unpublished data by Jojoba Growers and Processors, Inc. Comedogenicity study on Hydroba 70, a jojoba wax. jojoba Growers and Processors, Inc., Apache Junction, AZ (4 pages).1
33.
33. Yahagi, T., Nagao, M., Seino, Y., Matsushima, T., and Sugimura, T. (1977). Mutagenicities of N-nitrosamines on Salmonella. Mutat. Res.48(2), 121–129.
34.
34. Maron, D.M. and Ames, B.N. (1983). Revised methods for the Salmonella mutagenicity test. Mutat. Res.113, 173–215.
35.
35. Marshall, M.V., Noyola, A.J., and Brown, J.H. (1983). Testing for mutagenic activity in jojobutter-51. Soap, Cosmet., Chem. Spec.59(9), 40–2.
36.
36. CTFA. (1985). Submission of unpublished data by CTFA. CIR Safety Data Test Summary Response Form. Four-day clinical use test on a lip balm product containing 20.0% jojoba oil. No CTFA Code Number (1 page).'
37.
37. CTFA. (1985). Submission of unpublished data by CTFA. CIR Safety Data Test Summary Response Form. Human repeated insult patch test, phototoxicity test, and photoallergenicity test on a lip balm product containing 20.0% jojoba oil. No CTFA Code Number (4 pages).1
38.
38. CTFA. (1988). Submission of unpublished data by CTFA. CIR Safety Data Test Summary Response Form. Repeated insult patch test on a topical oil containing 0.5% jojoba oil. No CTFA Code Number (2 pages).1
39.
39. CTFA. (1985). Submission of unpublished data by CTFA. CIR Safety Data Test Summary Response Form. Two-day human outdoor use test on a sunscreen oil containing 0.5% jojoba oil. No CTFA Code Number (2 pages).1
40.
40. Windholz, M. (Editor). (1983). The Merck Index. An Encyclopedia of Chemicals Drugs, and Biologicals. New Jersey: Merck and Co., Inc. p. 755.
