Screening for Neurotoxicity: Application in the Toxicological Evaluation of Regulated Food Chemicals

1. U.S. Congress, Office of Technology Assessment (OTA). (1990). Neurotoxicity: Identifying and controlling poisons of the nervous system. OTA-Ba-436. Washington, DC: Government Printing Office.

2. Mcmillan, D. (1987). Risk assessment for neurobehavioral toxicity. Environ. Health Perspect. 76, 155–161.

3. National Research Council, National Academy of Sciences (NRC/NAS). (1984). Strategies to determine needs and priorities for toxicity testing. Washington, DC: National Academy Press.

4. Benz, D. (1989). Priority based assessment of food additives (PAFA Database). Washington, DC: Food and Drug Administration.

5. Federation of American Societies for Experimental Biology (FASEB), Life Sciences Research Office. (1986). Final Report: Predicting neurotoxicity and behavioral dysfunction from preclinical toxicologic data. Task Order #3, Contract No. FDA 223–83–2020. Washington, DC: Food and Drug Administration.

6. U.S. Food and Drug Administration (FDA). (1982). Toxicological principles for the safety assessment of direct food additives and color additives used in food. Available from National Technical Information Service: Springfield, VA. PB83–170696.

7. Mitchell, C.L. and Tilson, H.A. (1982). Behavioral toxicology in risk assessment: Problems and research needs. CRC Crit. Rev. Toxicol. 10, 265–274.

8. Anger, W.K. and Johnson, B.L. (1985). Chemicals affecting behavior. In: O'Donoghue, J.L. ed. Neurotoxicity of Industrial and Commercial Chemicals, Vol. 1. Boca Raton, FL: CRC Press.

9. Leukroth, R.W., ed. (1987). Predicting neurotoxicity and behavioral dysfunction from preclinical toxicologic data. Neurotoxicol. Teratol. 9, 395–471.

10. Reiter, L.W. (1987). Neurotoxicology in regulation and risk assessment. Devel. Pharmacol. Therap. 10, 354–368.

11. Spencer, P.S. and Schaumburg, H.H. , eds. (1980). Experimental and Clinical Neurotoxicology. Baltimore, MD: Williams and Wilkins.

12. Deuel, R.K. (1977). Determining sensory deficits in animals. In: Myers, R. , ed. Methods in Psychobiology, New York: Academic Press, pp. 99–125.

13. U.S. Environmental Protection Agency (EPA). (1985). Toxic Substances Control Act test guidelines final Rule. 40 CFR Part 798. Health effects testing guidelines. Subpart G—Neurotoxicity. Fed. Reg. 50, 39458–39470.

14. Gad, S.C. (1982). A neuromuscular screen for use in industrial toxicology. J. Toxicol. Environ. Health 9, 691–704.

15. Gad, S.C. (1989). Principles of screening in toxicology with special emphasis on applications to neurotoxicology. J. Am. Coll. Toxicol. 8, 21–27b.

16. Geller, I., Stebbins, W.C., and Wayner, M.J., eds. (1979). Test methods for definition of effects of toxic substances on behavior and neuromotor function. Conference proceedings. Neurobehav. Toxicol. 1, Supplement 1.

17. Marshall, J.F. , Turner, B.H. , and Teitelbaum, P. (1971). Sensory neglect produced by lateral hypothalamic damage. Science 174, 523–525.

18. Moser, V. , Mccormick, J. , Creason, J.P. , et al. (1988). Comparison of chlordimeform and carbaryl using a functional observational battery. Fund. Appl. Toxicol. 11, 189–206.

19. O'Donoghue, J.L. (1989). Screening for neurotoxicity using a neurologically based examination and neuropathology. J. Am. Coll Toxicol. 8, 97–115.

20. Spencer, P.S. , Bischoff, M.C. , and Schaumberg, H.H. (1980). Neuropathological methods for the detection of neurotoxic disease. In: Spencer, P.S. and Schaumberg, H.H. eds. Experimental and Clinical Neurotoxicology, Baltimore, MD: Williams and Wilkens.

21. Tilson, H.A. (1987). Behavioral indices of neurotoxicity: What can be measured? Neurotoxicol. Teratol. 9, 427–443.

22. Tupper, D.E. and Wallace, R.B. (1980). Utility of the neurological examination in rats. Acta Neurobiologiae Experimentalis 40, 999–1003.

23. World Health Organization (WHO). (1986). Principles and Methods for the Assessment of Neurotoxicity Associated with Exposure to Chemicals. Environmental Health Criteria Document #60. Geneva.

24. Wier, P.J. , Guerriero, F.J. , and Walker, R.F. (1989). Implementation of a primary screen for developmental neurotoxicity. Fund. Appl. Toxicol. 13, 118–136.

25. Buelke-Sam, J., Kimmel, C.A., and Adams, J., eds. (1985). Design considerations in screening for behavioral teratogens: Results of the collaborative behavioral teratology study. Conference proceedings. Neurobehav. Toxicol. Teratol. 7(6), 537–789.

26. U.S. Environmental Protection Agency (EPA). (1988). Diethylene glycol ethers: Test standards and requirements final rule. 40 CFR Parts 795 and 799. Fed. Reg. 53, 5931–5953.

27. Vorhees, C.V. , Butcher, R.E. , and Brunner, R.L. (1984). Developmental toxicity and psychotoxicity of potassium iodide in rats: A case for the inclusion of behaviour in toxicological assessment. Food Chem. Toxicol. 22, 963–970.

28. Vorhees, C.V. , Butcher, R.E. , Brunner, R.L. , and Sobotka, T.J. (1979). A developmental test battery for neurobehavioral toxicity in rats: A preliminary analysis using monosodium glutamate, calcium carrageenan, and hydroxyurea. Toxicol. Appl. Pharmacol. 50, 267–282.

29. Vorhees, C.V. (1987). Reliability, sensitivity and validity of behavioral indices of neurotoxicity. Neurotoxicol. Teratol. 9, 445–464.