Abstract
Many new drug candidates being developed within the pharmaceutical industry possess immunological activity, which may eventually necessitate an evaluation of potential toxicity to the immune system. At present, no consensus exists on which immunotoxicological procedures are most suitable for incorporation into the routine toxicology studies. This paper describes a few immunological test procedures that seem feasible for extrapolating to man, since similar approaches are now used clinically to evaluate immune reactivity. At present, data demonstrating the efficacy of immunotoxicological assays have been limited to humans exposed to environmental contaminants.
References
1.
1.
ASHER, I.M.
(ed). (1978 ). Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability . Washington, DC : Fourth FDA Science Symposium. Office of Health Affairs .
2.
2.
Davies, G.E.
(1983 ). In: Immunotoxicology .
G.G. Gibson
,
R. Hubbard
, and
D.V. Parke
(eds.). New York : Academic Press , p. 413 .
3.
3. MOLLER, G. (ed.). (1982 ). Immunol. Rev.
63 ,.
4.
4.
Dean, J.H.
,
Padarathsingh, M.D.
, and
Jerrells, T.R.
(1979 ). Drug Chem. Toxicol.
2 , 5 .
5.
5.
Dean, J.H.
,
Murray, M.J.
, and
Ward, E.C.
, (1984 ). In: Toxicology: The Basic Science of Poisons , 3rd ed.
J. Doull
,
C.D. Klaassen
, and
M.O. Amdur
(eds.). New York : Macmillan , chap. 9.
6.
6.
Dean, J.H.
,
Luster, M.I.
, and
Boorman, G.A.
(1982 ). In: Immunopharmacology .
P. Sirois
and
M. Rola-Pleszczynski
(eds.). Amsterdam : Elsevier , Vol. 4, chap. 14.
7.
7.
Vos, J.G.
(1977 ). CRC Crit. Rev. Toxicol.
5 , 67 .
8.
8.
Norbury, K.C.
(1982 ). Environ. Health Perspect.
43 , 53 .
9.
9.
Norbury, K.C.
(1982 ). Pharmacol. Rev.
34 , 131 .
10.
10.
Lewis, A.J.
,
Carlson, R.P.
, and
Chang, J.
(1982 ). Ann. Rep. Med. Chem.
17 , 191 .
11.
11.
Roberts, D.W.
, and
Chapman, J.R.
(1981 ). In: Developmental Toxicology .
C.A. Kimmel
and
J. Buelke-Sam
(eds.). New York : Raven Press , p. 167 .
12.
12.
Schmidt, R.R.
(1984 ). J. Am. Coll. Toxicol.
3 , 57 .
13.
13.
Golub, E.S.
(19 ). Cellular Basis of the Immune Response , 2nd ed.
Sunderland, MA : Sinauer Assoc. , pp. 237 –239 .
14.
14.
Moore, J.A.
,
Huff, J.E.
, and
Dean, J.H.
(1982 ). Pharmacol. Rev.
34 , 13 .
15.
15.
Speirs, R.S.
,
Benson, R.W.
, and
Schiffman, G.J.
(1978 ). Environ. Pathol. Toxicol.
1 , 689 .
16.
16.
Speirs, R.S.
, and
Speirs, E.E.
(1979 ). Drug Chem. Toxicol.
2 , 19 .
17.
17.
Benson, R.W.
, and
Roberts, D.W.
(1982 ). J. Toxicol. Environ. Health
10 , 859 .
18.
18.
Exon, J.H.
,
Koller, L.D.
,
Henningsen, G.M.
, and
Osborne, C.A.
(1984 ). Fund. Appl. Toxicol.
4 , 278 .
19.
19.
Han, T.
, and
Pauly, J.
(1972 ). Clin. Exp. Immunol.
11 , 137 .
20.
20. Norbury, K.C., and Noble, C. (1978). Fourth FDA Science Symposium. I.M. Asher (ed.). Washington, DC: Office of Health Affairs, p. 239.
21.
21.
Noble, C,
and
Norbury, K.C.
(1983 ). J. Immunopharm.
5 , 341 .
22.
22. Norbury, K.C., and Noble, C. Unpublished findings.
23.
23. Feldbush, T.L. Personal communication.
24.
24.
Gleichmann, H.
(1981 ). Clin. Immunol. Immunopathol.
18 , 203 .
25.
25. Noble, C., and Norbury, K.C. Manuscript in preparation.
26.
26.
Koller, L.D.
,
Exon, J.H.
, and
Norbury, K.C.
(1983 ). J. Toxicol. Environ. Health
12 , 173 .
27.
27.
Reynolds, C.W.
,
Sharrow, S.O.
,
Ortaldo, J.R.
, and
Herberman, R.B.
(1981 ). J. Immunol.
127 , 2204 .
28.
28.
HERBERMAN, R.B.
(ed.). (1980 ). Natural Cell-mediated Immunity Against Tumors . New York : Academic Press .
29.
29.
Parkinson, D.R.
,
Brightman, R.P.
, and
Waksal, S.D.
(1981 ). J. Immunol.
126 , 1460 .
30.
30.
GIBSON, G.G.
,
HUBBARD, R.
, and
PARKE, D.V.
(eds.). (1983 ). Immunotoxicology . New York : Academic Press .