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Abstract

The effects of T-2 toxin on a murine model of the acute phase response were studied. Two murine acute phase reactants, serum amyloid P component and plasma fibronectin, were measured after subcutaneous and intraperitoneal administration of T-2 toxin in varying doses. No acute phase response was observed. Furthermore, T-2 toxin also blocked the acute phase reaction to subcutaneous AgNO₃ in a dose-dependent fashion. These observations were not explained by damage to liver, the site of synthesis of acute phase proteins. Since the acute phase response is an immediate physiological reaction to tissue injury and may be a nonspecific participant in the repair phenomenon, its abrogation by T-2 toxin may contribute to the toxicity of this trichothecene mycotoxin.

References

1. Kushner, I. , Gewurz, H. , and Benson, M.D. (1981). C-reactive protein and the acute phase response. J. Lab. Clin. Med. 97(6), 739–749.

2. Mcadam, K.P.W.J. , Li, J. , Knowles, J. , Foss, N.T. , Dinarello, C.A. , Rosenwasser, L.J. , Selinger, M.J. Kaplan, M.M. , and Goodman, R. (1982). The biology of SAA: Identification of the inducer, in vitro synthesis, and heterogeneity demonstrated with monoclonal antibodies. In: C-Reactive Protein and the Plasma Protein Response to Tissue Injury. New York: New York Academy of Sciences, pp. 126–136.

3. Pepys, M.G. (1981). C-reactive protein fifty years on. Lancet 1, 653–657.

4. Pepys, M.G. , De Beer, F.C. , Dyck, R.F. , Baltz, M.L. , Holford, S. , Breathnach, S.M. , Black, M.M. , Tribe, C.R. , Evans, D.J. , and Feinstein, A. (1982). Biology of serum amyloid-P components. In: C-Reactive Protein and the Plasma Protein Response to Tissue Injury. New York: New York Academy of Sciences, pp. 286–298.

5. Glenner, G. (1980). Amyloid deposits and amyloidosis: the B-fibrilloses. N. Engl. J. Med. 302(23), 1283–1292.

6. Wyllie, T.D. , and Morehouse, L.G. (eds.). (1978). Mycotoxic Fungi, Mycotoxins, Mycotoxicoses. An Encyclopedic Handbook. Mycotoxicoses of Domestic and Laboratory Animals, Poultry and Aquatic Invertebrates and Vertebrates. New York: Marcel Dekker, Inc., Vol. 2.

7. Ueno, Y. (ed.). (1983). Developments in Food Sciences. IV: Trichothecenes–Chemical, Biological and Toxicological Aspects. Tokyo: Kodansha Ltd.; Amsterdam: Elsevier Science Publications BV. Chapter V: Toxicology–Immunological disorders, pp. 135–194; Chapter VI: Toxicoses, natural occurrence and control, pp. 195–307.

8. Gyongyossy-Issa, M.I.C. , and Khachatourians, G.G. (1984). Interaction of T-2 toxin with murine lymphocytes. Biochim. Biophys. Acta 803, 197–202.

9. Hayes, M.A. , and Schiefer, H.B. (1979). Quantitative and morphological aspects of cutaneous irritation by trichothecene mycotoxins. Food Cosmet. Toxic. 17, 611–621.

10.

10. Laurell, C.B. (1966). Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal. Biochem. 15, 45.

11.

11. Lee, S.C. , Beery, J.T. , and Chu, E.S. (1984). Immunoperoxidase localization of T-2 toxin. Toxicol. Appl. Pharmacol. 72, 228–235.

12.

12. Saba, T.M. , and Jaffe, E. (1980). Plasma fibronectin (opsonic glycoprotein): Its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. Am. J. Med. 68, 577–594.

13.

13. Dyck, R.F., Bingham, W., Tan, L., and Rogers, S.L. (1984). Serum levels of C-reactive protein in neonatal distress syndrome. Clin. Pediatr. (In press).

The Effect of T-2 Toxin on the Acute Phase Reaction in Mice

Abstract

References