The Effect of T-2 Toxin on the Acute Phase Reaction in Mice

Abstract

The effects of T-2 toxin on a murine model of the acute phase response were studied. Two murine acute phase reactants, serum amyloid P component and plasma fibronectin, were measured after subcutaneous and intraperitoneal administration of T-2 toxin in varying doses. No acute phase response was observed. Furthermore, T-2 toxin also blocked the acute phase reaction to subcutaneous AgNO₃ in a dose-dependent fashion. These observations were not explained by damage to liver, the site of synthesis of acute phase proteins. Since the acute phase response is an immediate physiological reaction to tissue injury and may be a nonspecific participant in the repair phenomenon, its abrogation by T-2 toxin may contribute to the toxicity of this trichothecene mycotoxin.

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