3 Addendum to the Final Report on the Safety Assessment of Benzophenones-1,3,4,5,9,and 11 to Include Benzophenones-2,6,and 8

1. COSMETIC, TOILETRY, AND FRAGRANCE ASSOCIATION (CTFA). (1980c). Submission of data by CTFA. Supplementary mutagenesis data.*

2. DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (DHEW). (May 1978). Submission of data by CTFA. Unpublished data on Benzophenone, Appendix 5b.*

3. DHEW. (Feb. 1979). Submission of data by CTFA. Unpublished data, Appendix 5c*

4. HILL TOP RESEARCH LABS. (June 1979a). Submission of data by CTFA. Unpublished data on Benzophenone, Appendix 3a.*

5. HILL TOP RESEARCH LABS. (Sept. 1979b). Submission of data by CTFA. Unpublished data, Appendix 3b.*

6. Prival, M.J. , Sheldon, A.T., Jr. , and Popkin, D. (1982). Evaluation, using Salmonella typhimurium, of the mutagenicity of seven chemicals found in cosmetics. Food Chem. Toxicol. 20, 427–32.

7. LITTON BIONETICS. (1979). Submission of data by CTFA. Supplementary mutagenesis data.*

8. McMAHON, R.E. , Cline, J.C. , and Thompson, C.Z. (1979). Assay of 855 test chemicals in ten tester strains using a new modification of the Ames test for bacterial mutagens. Cancer Res. 39, 682–93.

9. LILLY RESEARCH LABS. (May 1982a). Submission of data by CTFA. The effect of benzophenone-2 on the induction of bacterial mutation using a modification of the Ames test, Study 820510GPA1876.*

10. LILLY RESEARCH LABS. (May 1982b). Submission of data by CTFA. The effect of benzophenone-6 on the induction of bacterial mutation using a modification of the Ames test. Study 820510GPA1877.*

11. LILLY RESEARCH LABS. (June 1982c). Submission of data by CTFA. The effect of benzophenone-2 on the induction of DNA repair synthesis in primary cultures of adult rat hepatocytes, Study 820511UDS1876.*

12. LILLY RESEARCH LABS. (June 1982d). Submission of data by CTFA. The effect of benzophenone-6 on the induction of DNA repair synthesis in primary cultures of adult rat hepatocytes, Study 820511UDS1877.*

13. LILLY RESEARCH LABS. (May 1982e). Submission of data by CTFA. The effect of benzophenone-2 on the in vivo induction of sister chromatid exchange in bone marrow of Chinese hamsters, Study 820504SCE1876.*

14. LILLY RESEARCH LABS. (May 1982f). Submission of data by CTFA. The effect of benzophenone-6 on the in vivo induction of sister chromatid exchange in bone marrow of Chinese hamsters, Study 820510SCE1877.*

15. LITTON BIONETICS. (Oct. 1981). Submission of data by CTFA. Mutagenicity evaluation of benzophe-none-8 in the sister chromatid exchange assay with Chinese Hamster Ovary (CHO) cells final report.*

16. PHARMAKON RESEARCH INTERNATIONAL. (Dec. 9,1981a). Submission of data by CTFA. CHO/HGPRT mammalian cell forward gene mutation assay, PH314-AC-001-81, Benzophenone-8.*

17. PHARMAKON RESEARCH INTERNATIONAL. (Oct. 30, 1981b). Submission of data by CTFA. Genetic toxicology micronucleus test (MNT), PH309A-AC-002-81, Benzophenone-8.*