Pairs of depressed patients were matched for age, sex, and severity of depression, and treated for four weeks with nortriptyline so that plasma levels of below 49 ng/ml and above 140 ng/ml were, obtained.
Comparisons of pairs of patients as regards to improvement of depression, using a sequential skew restricted design, suggested that it was unlikely that a significant difference between the two treatment regimes would be detected.
References
1.
AlexandersonB.Price-EvansD. A.SjöqvistF. (1969). Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy. British Medical Journal, IV: 764.
2.
ArmitageP. (1960). Sequential Medical Trials. Oxford University Press, Oxford.
3.
AsbergM.CrönholmB.SjöqvistF.TuckD. (1971). Relationship between plasma level and therapeutic effect of nortriptyline. British Medical Journal, 3: 331.
4.
BlashkiT. G.MowbrayR.DaviesB. (1971). Controlled trial of amitriptyline in general practice. British Medical Journal, 1: 133.
5.
BraithwaiteR. A.GouldingR.TheanoG.BaileyJ.CoppenA. (1972). Plasma concentration of amitriptyline and clinical response. Lancet, 1: 1297.
6.
BurrowsG. D.DaviesB.ScogginsB. A. (1972). Plasma concentration of nortriptyline and clinical response in depressive illness. Lancet, 2: 619.
7.
BurrowsG. D. (1972). Clinical and pharmacological studies in depressive illness. M.D. Thesis, University of Melbourne.
8.
BurrowsG. D.ScogginsB. A.DaviesB. (1973). Plasma nortriptyline and clinical response. Clinical Pharmacology and Therapeutics (in press).
9.
CarrollB. J.MowbrayR. M.DaviesB. (1970). Sequential comparison of L-Tryptophan with E.C.T. in severe depression. Lancet, 1: 967.
10.
HamiltonM. J. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23: 56.
11.
HammerW. M.BrodieB. (1967). Application of isotope derivative technique to the assay of secondary amines and estimation of desipramine by acetylatone with H3-acetate anhydride. Journal of Pharmacology and Experimental Therapeutics, 157–503.
