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Abstract

Background

Fatigue is a common symptom of chronic rhinosinusitis (CRS), but the response of fatigue to endoscopic sinus surgery (ESS) is rarely studied.

Methods

A prospective, open cohort of adult patients undergoing ESS for CRS was studied using 10-cm fatigue visual analog scales (VASs), Lund-MacKay computed tomography (CT), and Lund-Kennedy nasal endoscopy scoring.

Results

Two hundred seventy-two patients, followed for a mean (±SD) of 16.5 ± 8.5 months after ESS, noted significant fatigue improvement with an effect size defined as large by Cohen (0.8 [95% CI, 0.5–1.3]). Neither preoperative CT scores nor preoperative endoscopy scores correlated with preoperative fatigue severity. Compared with the mean preoperative fatigue score (6.1 ± 2.9 cm), preoperative fatigue was more severe in women (6.9 ± 2.6 cm; p < 0.001) patients with depression (7.7 ± 2.4 cm; p < 0.001) and patients with fibromyalgia (7.9 ± 2.2 cm; p = 0.013), but less severe in patients with nasal polyposis (5.4 ± 3.2 cm; p = 0.009). Significantly greater postoperative reduction in fatigue was noted in patients with fibromyalgia when compared with study patients without fibromyalgia (effect size = 1.8 [95% CI, 1.6–2.2]; p > 0.001) with final fatigue severity scores similar to the entire study group. Similarly, patients with severe fatigue (n = 112; mean VAS score, 8.8 ± 0.8 cm) showed a more pronounced improvement than patients less severely fatigued (n = 160; mean VAS score 4.2 ± 2.4 cm; effect size = 2.2 [95% CI, 2.0–2.9]; p > 0.001).

Conclusion

Fatigue improves after ESS, with significantly greater improvement in patients with fibromyalgia and in patients that are more severely fatigued at presentation.

Keywords

Chronic rhinosinusitis endoscopic endoscopic sinus surgery fatigue fibromyalgia Lund-MacKay outcomes quality of life sinusitis visual analog scales

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The Effects of Endoscopic Sinus Surgery on Level of Fatigue in Patients with Chronic Rhinosinusitis

Abstract

Background

Methods

Results

Conclusion

Keywords

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References