Restricted accessResearch articleFirst published online 1998-1
Nasal Polyps and Their Relation to Polyps/Hypertrophic Polypoid Mucosa in the Paranasal Sinuses: A Macro-,Endo-,and Microscopic Study of Autopsy Materials
The present study comprised macro- and endoscopic screening of the nasosinusal complex in 56 autopsies, 24 with nasal polyps and 32 without. Seven had nasal polyposis (bilaterally more than two). Hypertrophic polypoid mucosa in the paranasal sinuses was not found in the cases with nasal polyposis and in only 2 (4%) of the total number (24) of cases with polyps. Microscopic examination of nine small polyps, the mucosa from which they originated, and control specimens showed accumulation of eosinophils in the mucosa from which the polyps originated, indicating localized inflammation.
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References
1.
CaunaN., ManzettiG.W., HindererK.H.Swanson EW. Fine structure of nasal polyps.Ann Otol Rhinol Laryngol81: 41–58, 1972.
2.
OgawaH.A.Possible role of aerodynamic factors in nasal polyp formation.Acta Otolaryngol (Stockh) Suppl430: 18–20, 1986.
TosM., LarsenP.L.Møller K. Goblet cell density in nasal polyps.Ann Otol Rhinol Laryngol99: 310–315, 1990.
5.
LarsenP.L., TosM.Nasal polyps: Epithelium and goblet cell density.Laryngoscope99: 1274–1280, 1990.
6.
SofsrudG., LarsenP.L., FranzmannM., TosM.Density of inflammatory cells in nasal polyps. Critical analyses.Preliminary results (in preparation).
7.
JahnsenF.L., HaraldsenG., HayeR., BrandtzaegP.Adhesion molecules and recruitment of eosinophils. In: MygindN., LildholtT., Eds. Nasal Polyposis: An Inflammatory Disease and its Management.Mungsgaard, Copenhagen, 1997.
8.
BachertC.Cytokines: Comparison between polyp tissue, diseased sinus mucosa and normal nasal tissue. In: MygindN., LildholtT., Eds. Nasal Polyposis: An Inflammatory Disease and its Management, Mungsgaard, Copenhagen, 1997.
9.
DenburgJ. Cytokines and inflammatory cells. In: MygindN., LildholtT., Eds. Nasal Polyposis: An Inflammatory Disease and its Management.Munksgaard, Copenhagen, 1997.
10.
LinderA., Karlsson-ParaA., HirvelaC.Immunocompetent cells in human nasal polyps and normal mucosa.Rhinology31: 125–129, 1993.
11.
ZuckerkandlE.Normale und Pathologische Anatomie der Nasenhohle und ihrer Pneumatische anhange.Wilhelm Braumuller, Wien 1882.
12.
SuttnerH.J., HosemannW., RockeleinG.Histologische Stufenschnitt-Untersuchungen an Siebbeinpraparaten bei Polyposis Nasi.Eur Arch Otorhinolaryngol11:360(suppl), 1992.
13.
JahnsenF.L., HaraldsenG., AanesenJ.P.Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps.Am J Resp Cell Mol Biol12: 624–632, 1995.
14.
OhnishiM., RuhnoJ., BienenstockJ.Human nasal polyp epithelial basophil/mast cell and eosinophil colony-stimulating activity. The effect is T-cell dependent.Am Rev Resp Dis138: 560–564, 1988.
15.
TingsgaardP.K., LarsenP.L., BockT., Lange VejlsgaardG., TosM.Expression of intercellular adhesion molecule-1 on the vascular endothelium in nasal polyps before, during and after topical glucocorticoid treatment.Acta Otolaryngol (Stockh), accepted.
16.
HolmA.F., FokkensW.J., GodthelpT.Effect of 3 months nasal steroid therapy on nasal T cells and Langerhans cells in patients suffering from allergic rhinitis.Allergy50: 204–209, 1995.
DawesP., BatesG., WatsonD.The role of bacterial infection of the maxillary sinus in nasal polyps.Clin Otolaryngol14: 447–450, 1989.
19.
van CampC., ClementP.A.R.Results of oral steroid treatment in nasal polyposis.Rhinology32: 5–9, 1994.
20.
Drake-LeeA.B.Medical treatment of nasal polyps.Rhinology32: 1–4, 1994.
21.
LarsenP.L., TosM.Origin of nasal polyps.Laryngoscope101: 305–312, 1991.
22.
LarsenP.L., TosM.Site of origination of nasal polyps. Transcranially removed naso-ethmoidal blocks as a screening method for nasal polyps in an autopsy material.Rhinology33: 185–188, 1995.
23.
LarsenP.L., TosM.Anatomic site of origin of nasal polyps: Endoscopic nasal and paranasal sinus surgery as a screening method for nasal polyps in an autopsy material.Am J Rhinol10: 211–216, 1996.
24.
LarsenP.L., TosM., BaerS.En bloc removal of the ethmoid and ostiomeatal complex in cadavers with a practical application.Rhinology32: 62–64, 1994.
25.
MantoniM., LarsenP.L., HansenH., TosM.Coronal CT of the paranasal sinuses before and after functional endoscopic sinus surgery.Eur Radiol6: 920–924, 1996.
26.
LarsenP.L., TosM., KuijpersW., van der BeekJ.M.H.The early stages of polyp formation.Laryngoscope102: 670–677, 1992.
27.
LarsenP.L., TosM.Ear polyps in posterior superior retraction pockets, herodion. Histopathological and pathogenetic aspects.ORL54: 328–330, 1992.
