Sensory, parasympathetic, and sympathetic nerves innervate many structures in airways. The anatomy, histology, and function of these nerves and their varied neurotransmitters will be reviewed. Changes that may contribute to the pathophysiology of allergic, viral, and nonallergic rhinitis will be described.
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References
1.
LundbladL.Protective reflexes and vascular effects in the nasal mucosa elicited by activation of capsaicin-sensitive substance P-immunoreactive trigeminal neurons.Acta Physiol Scand Suppl529: 1–42, 1984.
2.
HuaX.Y.Tachykinins and calcitonin gene related peptide in relation to peripheral functions of capsaicin-sensitive sensory nerves.Acta Physiol Scand 127 Suppl551: 1–45, 1986.
3.
UddmanR., SundlerF.Innervation of the upper airways.Clin Chest Med7: 201–209, 1986.
4.
BarnesP.J., BaraniukJ.N., BelvisiM.G.Neuropeptides in the respiratory tract. Part 1.Am Rev Respir Dis144: 1187–1198, 1991.
5.
BarnesP.J., BaraniukJ.N., BelvisiM.G.Neuropeptides in the respiratory tract. Part 2.Am Rev Respir Dis144: 1391–1399, 1991.
6.
BaraniukJ.N.Neural control of human nasal secretion.Pulm Pharmacol4: 20–31, 1991.
7.
RaphaelG.R., BaraniukJ.N., KalinerM.A.How and why the nose runs.J Allergy Clin Immunol87: 457–467, 1991.
8.
CaunaN.Blood and nerve supply of the nasal lining. In The Nose: Upper Airway Physiology and the Atmospheric Environment. Ch. 3ProctorD.F., AndersonI. (Eds) Amsterdam: Elsevier Biomedical Press BV, 45–69, 1992.
9.
LundbergJ.M.Pharmacology of cotransmission in the autonomic nervous system: Integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids, and nitric oxide.Pharmacol Rev48: 113–178, 1996.
10.
DrayA., UrbanL., DickensonA.Pharmacology of chronic pain.TIPS15: 190–197, 1994.
11.
DemskiL.S., Schwanzel-FukudaM., Eds. The terminal nerve (nervus terminalis).Ann N Y Acad Sci519: 1–213, 1987.
12.
BarrM.L.The human nervous system.2nd ed.Hagerstown, MD: Harper & Row, 1974.
13.
ChenZ., HednerJ., HednerT.Local effects of substance P on respiratory regulation in the rat medulla oblongata.J Appl Physiol68: 693–699, 1990.
14.
BaraniukJ.N., LundgrenJ.D., GoffJ.Bradykinin receptor distribution in human nasal mucosa, and analysis of in vitro secretory responses in vitro and in vivo.Am Rev Respir Dis141: 706–714, 1990.
15.
MartinsM.A., ShoreS.A., DrazenJ.M.Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs.Am J Physiol261(Lung Cell: Mol Physiol. 5): L449–L455, 1991.
16.
RaphaelG.D., IgarashiY., WhiteM.V., KalinerM.A.The pathophysiology of rhinitis. V. Sources of protein in allergen-induced nasal secretions.J Allergy Clin Immunol88: 33–43, 1991.
17.
BaraniukJ.N., LundgrenJ.D., GoffJ.Calcitonin gene related peptide (CGRP) in human nasal mucosa.Am J Physiol258: L81–L88, 1990.
18.
BaraniukJ.N., LundgrenJ.D., GoffJ.Gastrin releasing peptide (GRP) in human nasal mucosa.J Clin Invest85: 998–1005, 1990.
19.
HolzerP.Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene related peptide, and other neuropeptides.Neuroscience24: 739–768, 1988.
20.
McDonaldD.M.Neurogenic inflammation in the rat trachea. I. Changes in venules, leukocytes, and epithelial cells.J Neurocytol17: 605–628, 1988.
21.
BaraniukJ.N., LundgrenJ.D., OkayamaM.Substance P and neurokinin A (NKA) in human nasal mucosa.Am J Respir Cell Mol Biol4: 228–236, 1991.
22.
CarstairsJ.R., BarnesP.J.Autoradiographic mapping of substance P receptors in lung.Eur J Pharamacol127: 295–296, 1988.
23.
NadelJ.A.Decreased neutral endopeptidases: Possible role in inflammatory diseases of airways.Lung123(Suppl): 123–127, 1990.
BorsonD.B.Roles of neutral endopeptidase in airways.Am J Physiol260(Lung Cell: Mol Physiol 4): L212–L225, 1991.
26.
NobleF., DaugeV., Fournie-ZaluskiM.C., BeaumontA.Neutral endopeptidase 24.11: Structure, inhibition, and experimental and clinical pharmacology.Pharmacolog Rev45: 87–146, 1993.
27.
BaraniukJ.N., OkayamaM., LundgrenJ.D.Vasoactive intestinal peptide (Vi.p.) in human nasal mucosa.J Clin Invest86: 825–831, 1990.
28.
KobzikL., BredtD.S., LowensteinC.J.Nitric oxide synthetase in human and rat lung: Immunocytochemical and histochemical localization.Am J Respir Cell Mol Biol9: 371–377, 1993.
29.
WatsonN., MaclaganJ., BarnesP.J.Vagal control of guinea pig tracheal smooth muscle: Lack of involvement of Vi.p. or nitric oxide.J Appl Physiol74: 1964–1971, 1993.
MakJ.C.W., BarnesP.J.Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung.Am Rev Respir Dis141: 1559–1568, 1990.
34.
DorjeF., WessJ., LambrechtG.Antagonist binding profiles of five cloned human muscarinic receptor subtypes.J Pharmacol Exp Ther256: 727–733, 1991.
35.
OkayamaM., BaraniukJ.N., MeridaM., KalinerM.A.Autoradiographic localization of muscarinic receptor subtypes in human nasal mucosa.Am J Respir Cell Mol Biol8: 176–185, 1993.
36.
RichersonH.B., SeebohmP.B.Nasal airway response to exercise.J Allergy41: 269–284, 1968.
37.
BaraniukJ.N., CastellinoS., GoffJ. (1990a) Neuropeptide Y (NPY) in human nasal mucosa.Am. J. Respir. Cell. Mol. Biol.3, 165–173, 1990.
38.
LacroixJ.S., AnggardA., HokfeltT.Neuropeptide Y: Presence in sympathetic and parasympathetic innervation of the nasal mucosa.Cell Tissue Res259: 119–128, 1990.
39.
LacroixJ.C., MosimmanB.L.Attenuation of allergen-evoked nasal responses by local pretreatment with exogenous neuropeptide Y in atopic patients.J Allergy Clin Immunol98: 611–616, 1996.
40.
BarnesP.J.Modulation of neurotransmission in airways.Physiol Rev72: 699, 1992.
41.
MullolJ., BaraniukJ.N., LogunC.M1 and M3 muscarinic antagonists inhibit human nasal glandular secretion in vitro.J Appl Physiol73: 2069–2073, 1992.
42.
MakJ.C.W., BaraniukJ.N., BarnesP.J.Localization of muscarinic receptor subtype mRNAs in human lung.Am J Respir Cell Mol Biol7: 344–348, 1992.
43.
SmithC.H., BarkerJNWN, MorrisR.W.Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin.J Immunol151: 3274–3282, 1993.
44.
MossimanB.L., WhiteM.V., HohmanR.J.Substance P, calcitonin-gene related peptide, and vasoactive intestinal peptide increase in nasal secretions after allergen challenge in atopic patients.J Allergy Clin Immunol92: 95–104, 1993.
45.
TomakiM., IchinoseM., MiuraM.Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis.Am J Respir Crit Care Med151: 613–617, 1995.
46.
BaiT.R., ZhouD., WeirT.Substance P (NK1)-, and Neurokinin A (NK2)-receptor expression in inflammatory airway disease.Am J Physiol269(Lung Cell Mol Physiol 13): L309–L317, 1995.
47.
OkayamaY., ShirotoriK., KudoK.Cytokine expression after the topical administration of substance P to human nasal mucosa.J Immunol151: 4391–4398, 1993.
48.
BaraniukJ.N., SilverP.B., KalinerM.A., BarnesP.J.Perennial rhinitis subjects have altered vascular, glandular, and neural responses to bradykinin nasal provocation.Int Arch Allergy Immunol103: 202–208, 1994.
49.
RicchioM.M., ReynoldsC.J., HayD.W., ProudD.Effects of intranasal administration of endothelin-1 to allergic and nonallergic individuals.Am J Respir Crit Care Med152: 1757–1764, 1995.
50.
RicchioM.M., ProudD.Evidence that enhanced neural reactivity to bradykinin in patients with symptomatic allergy is mediated by neural reflexes.J Allergy Clin Immunol97: 1252–1253, 1996.
StjarneP., LundbladL., LundbergJ.M., AnggardA.Capsaicin and nicotine sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis.Br J Pharmacol96: 693–701, 1989.
RaphaelG.D., Haupstein-RaphaelM., KalinerM.A.Gustatory rhinitis: a syndrome of food-induced rhinorrhea.J Allergy Clin Immunol83: 110–115, 1989.
55.
StjarneP., LacroixJ.S., AnggardA., LundbergJ.M.Compartment analysis of vascular effects of neuropeptides and capsaicin in the pig nasal mucosa.Acta Physiol Scand141: 335–342, 1991.
56.
WillesS., FitzgeraldT., BascomR.Nasal inhalation challenge studies with sidestream tobacco smoke.Arch Environ Health47: 223–230, 1992.
57.
StoneR.A., FullerR.W.Mechanisms of cough. In Asthma and Rhinitis,BusseW.W., HolgateS.T. (Eds) Blackwell, Oxford, 1995, 1075–1083.
BuccaC., RollaG., ScappaticciE., ChiampF., BugianiM., MagnanoM., D'AlbertoM.Extrathoracic and intrathoracic airway responsiveness in sinusitis.J Allergy Clin Immunol95: 52–59, 1995.
60.
AndersonS.A., TogiasA.G.Dry air and hyperosmolar challenge in asthma and rhinitis. In Asthma and Rhinitis,BusseW.W., HolgateS.T. (Eds) Marcel Dekker, New York, 1995, 1178–1195.
61.
TaddeseA., NahS.Y., McCleskeyE.W.Selective opioid inhibition of small nociceptive neurons.Science270: 1366–1369, 1995.
62.
BolserD.C., O'ReillyS., DeGennaroF.C., HeyJ.A.Antitussive activity of NK1 and NK2 antagonists in the guinea pig and cat.Am J Respir Crit Care Med151: A816, 1995.
63.
BaraniukJ.N., OhkuboK., KwonO.J.Localization of neutral endopeptidase (NEP) mRNA in human bronchi.Eur Respir J8: 1458–1464, 1995.
64.
LurieA., NadelJ.A., RoismanG.Role of neutral endopeptidase and kininase II on substance P-induced increase in nasal obstruction in patients with allergic rhinitis.Am J Respir Crit Car Med149: 113–117, 1994.
65.
CheungD., BelE.H., den HartighJ.The effect of inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo.Am Rev Respir Dis145: 1275–1280, 1992.
66.
CrimiN., PalermoF., OliveriR.Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects.Clinical Allergy18: 375–382, 1988.
