Abstract
Neuropeptides are present within the nasal cavity and are thought to mediate inflammation in this region. The exact role these peptides might play in causing the inflammation present in chronic rhinosinusitis and nasal polyposis is not known. Calcitonin Gene Related Peptide (CGRP) was measured in the nasal secretion and nasal mucosa of 10 patients having chronic rhinosinusitis and 10 patients with nasal polyposis, using radioimmunoassay. These values were compared to ten controls without sinonasal disease. Additionally, each subject's history and baseline laboratory data were analyzed to establish the presence or absence of allergic disease. The results of these assays are discussed, as well as the potential pathophysiologic role that neuropeptides play in these disease states.
Get full access to this article
View all access options for this article.