The mucociliary activity in the rabbit maxillary sinus is stimulated by exogenous substance P and by histamine (via H1 receptors). Also, endogenous substance P released by capsaicin stimulates the mucociliary activity. A substance P-induced release of histamine has been reported. The possibility that the mucociliary stimulation by substance P is secondary to a release of histamine was investigated using a photoelectric technique. For both substance P (0.01, 0.1, and 1.0 μg/kg) and capsaicin (15 and 30 μg/kg), neither the maximum mucociliary response nor the time-course curve was affected by pretreatment with the H,-antagonist pyrilamine (4 mg/kg). It is concluded that the mucociliary effects produced by substance P and capsaicin are not secondary to a release of histamine.
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