To explore biochemical relationships between naturally occurring allergic rhinitis and a nasal provocation model, we measured PGD2 and LTC4 content of nasal rinses obtained before and after nasal allergen challenge, in and out of the allergy season. Both PGD2 and LTC4 contents rose after challenge. The rise in season was substantially greater than that seen out of season, and the amounts of eicosanoids present after acute challenge out of season were greater than those recovered when the patients were symptomatic in season. Eicosanoid response is quantitatively different with chronic environmental exposure and with acute laboratory provocation.
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