High molecular weight neutrophil chemotactic activity has been identified in resected human nasal polyps, inferior turbinates, and nasal secretions following antigen challenge. The estimated molecular weight, by gel filtration chromatography, was approximately 600,000. However, a heterogeneity of molecular weight in some patients was recognized. Our results suggest a possible role for high molecular weight-neutrophil chemotactic activity in the pathogenesis of hypersensitivity in the human nasal cavity.
Get full access to this article
View all access options for this article.
References
1.
MathewsK.P.Mediators of anaphylaxis, anaphylactoid reactions, and rhinitis. Am J Rhinol1: 17–26, 1987.
NagyL., LeeT.H., KayA.B.Neutrophil chemotactic activity in antigen-induced late asthmatic reactions. N Engl J Med306: 497–501, 1982.
4.
AtkinsP.C., NormanM., WeinerH., ZweimanB.Release of neutrophil chemotactic activity during immediate hypersensitivity reaction in humans. Ann Intern Med86: 415, 1977.
5.
WassermanS.I., SoterN.A., CenterD.M., AustenK.F.Cold urticaria: recognition and characterization of a neutrophil chemotactic factor, which appears in serum during experimental cold challenge. J Clin Invest60: 189–196, 1977.
6.
SoterN.A., WassermanS.I., AustenK.F., McFaddenE.R.Release of mast cell mediators and alterations in lung function in patients with cholinergic urticaria. N Engl J Med302: 604–608, 1980.
7.
AtkinsP.C., ZweimanB.Mediator release in local heat urticaria. J Allergy Clin Immunol68: 286–289, 1981.
8.
LeeT.H., NagyL., NagakuraT., WalportM.J., KayA.B.Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma. J Clin Invest69: 889–899, 1982.
LeeT.H., NagakuraT., PapageorgiouN., likuraY., KayA.B.Exercise-induced late asthmatic reactions with neutrophil chemotactic activity. N Engl J Med308: 1502, 1983.
11.
MackayJ.A., CromwellO., KayA.B.Allergen-induced release of high molecular weight neutrophil chemotactic activity in nasal secretions from patients with allergic rhinitis (Abstract). J Allergy Clin Immunol77: 183, 1986.
12.
KalinerM., WassermanS.I., AustenK.F.Immunologic release of chemical mediators from human nasal polyps. N Engl J Med289: 277–281, 1973.
13.
CarrollM.P., DurhamS.R., WalshG., KayA.B.Activation of neutrophils and monocytes after allergen- and histamine-induced bronchoconstriction. J Allergy Clin Immunol75: 290–296, 1985.
14.
LeeT.H., NagyL., NagakuraT., WalportM.J., KayA.B.Physicochemical and biological properties of an exercise-induced, asthma-associated neutrophil chemotactic factor (Abstract). Fed Proc41: 734, 1982.
