An animal model for rhinogenic sinusitis was developed in rabbits naturally colonized with Bordetella bronchiseptica. It was found that ostial occlusion predisposes the sinus to invasion with this opportunistic bacterium and subsequent sinusitis as a result of reduced local host defense. In addition to the inflammatory lesions in the sinus, bronchitis and pneumonia were found in 84% of the experimental rabbits, suggesting that ostial dysfunction can also contribute to infectious disease of the lower respiratory tract. In such a model it is possible to study the significance of asymptomatic carriage of potential pathogens after ostial occlusion.
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References
1.
NegusV.Comparative studies of the anatomy and physiology of the nose and paranasal sinuses.London: 1958.
2.
KumlienJ., SchiratzkiH.The vascular arrangements of the sinus. A study in rabbits. Acta Otoralyngol (Stockh)99: 630–636, 1985.
WestrinK., StiernaP., KumlienJ., CarlsööB., NordC.E.Induction, course, and recovery of maxilary sinusitis: A bacteriological and histological study in rabbits. Am J Rhinol4: 55–66, 1990.
8.
WestrinK., StiernaP., CarlsööB., NordC.E.Mucosubstance histochemistry of the maxillary sinus mucosa in experimental sinusitis: A model study on rabbits. ORL53: 299–304, 1991.
9.
WestrinK., NorlanderT., StiernaP., CarlsööB., NordC.E.Experimental maxillary sinusitis induced by Bacteroides fragilis. A bacteriological and histological study in rabbits. Acta Otoralyngol (Stockh)112: 107–114, 1992.
10.
DuclosP., CailletJ., JavelotP.Flore bactérienne aérobie des cavites nasales du lapin d'élevage. Ann Rech Vét17: 185–190, 1986.
11.
LundbergC.Concentration of penicillin and tetracycline in maxillary sinus mucosa and secretion. Doctoral dissertation, Stockholm1994.
12.
AustR., DrettnerB.The patency of the maxillary ostium in relation to body posture. Acta Otoralyngol (Stockh)80: 443–446, 1975.
13.
RobbinsS.L.Pathologic basis of disease.Philadelphia: WB Saunders Co., 847–851, 1974.
14.
KirchnerB.K., MagocT.J., SidorM.A.Pasteurella pneumotropica in rabbits from a “Pasteurella-free” production colony. Lab Anim Sci33: 461–462, 1983.
MannW., TrongH.D.Vergleichende endoskopische und histologische befunde bei chronischer sinusitis. HNO27: 345–347, 1979.
17.
HosemannW., WigandM.E.Örtliche unterschiede im gewebebild der chronisch-hyperplastischen nasennebenhöhlenschleimhaut. HNO33: 311–315, 1985.
18.
CorrenJ., RachelefskyG.S.Interrelationship between sinusitis and asthma. Immunol Allergy Clin N Am14: 171–184, 1994.
19.
BrugmanS.M., LarsenG.L., HensonP.M.Increased lower airways responsiveness associated with sinusitis in a rabbit model. Am Rev Respir Dis147: 314–320, 1993.
20.
SeniorB.A., KennedyD.W.Management of sinusitis in the asthmatic patient. (review). Ann Allergy Asthma Immunol77: 6–15, 1996.
21.
MarneyS.R.Pathophysiology of reactive airway disease and sinusitis. Ann Otol Rhinol Laryngol105: 98–100, 1996.
