Reduction of immunity in 11 mice of the CD1 strain by administration of methotrexate did not alter some reliable behaviors in the open-field (ambulation, rearing, defecation) compared with 10 matched mice injected with saline. Perhaps moderate depression of immunity may not affect some characteristic behaviors.
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References
1.
BaggottJ. E.MorganS. L.FreebergL. E.HudsonB. B.VaughW. H.NairM. G.KrumdieckC. L.KoopmanW. J.GayR. E.GayS. (1992) Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin. Agents and Actions, 35, 104–111.
2.
BarnardC. J.BehnkeJ. M.GageA. R.BrownH.SmithurstP. R. (1997) Modulation of behaviour and testosterone concentration in immunodepressed male laboratory mice (Mus musculus). Physiology & Behavior, 61, 907–917.
3.
GomáM.TobeñaA. (1978) Reliability of various measures obtained in open-field test. Psychological Reports, 43, 1123–1128.
4.
SimmelE. C.BagwellM. (1983) Genetics of exploratory behavior and activity. In FullerJ. L.SimmelE. C. (Eds.), Behavior genetics: Principles and applications. Hillsdale, NJ: Erlbaum. Pp. 85–115.
5.
WinkelsteinA. (1994) Immunosuppressive therapy. In StitesD. P.TerrA. I.ParslowT. G. (Eds.), Basic and clinical immunology. (8th ed.) London: Prentice-Hall. Pp. 765–780.
