Restricted accessResearch articleFirst published online 1993-2
Extreme Hypothermia Induced by a Synergism of Acute Limbic Seizures,Physical Restraint,and Acepromazine: Implications for Survival following Brain Injury
Core temperature was measured in rats 24 hr. after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine. An extraordinarily powerful interaction was noted among seizures, physical restraint, and acepromazine-produced hypothermia (24° C) compared to the other 7 treatments (> 35° C). The putative poikilothermic response is commensurate with the loss of mammalian behaviors that follow these seizures. Implications for survival during the acute stages of brain injury are suggested.
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References
1.
BuchanA.PulsinelliW. A.Hypothermia but not the n-methyl-d-aspartate antagonist MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. The Journal of Neuroscience, 1990, 10, 311–318.
2.
BureauY. R. J.PersingerM. A.Cholinergic rebound after chlorpromazine exacerbates lithium muscarinic-induced limbic seizures in rats, implications for psychiatric treatment. Psychological Reports, 1991, 69, 171–176.
3.
BureauY. R. J.PersingerM. A.Geomagnetic activity and enhanced mortality in rats with acute (epileptic) limbic lability. International Journal of Biometeorology, 1992, 36, 226–232.
4.
FadenA. I.DemediukP.PanterS. S.VinkR.The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science, 1989, 244, 798–800.
5.
HayesD. L.LyethB. G.JenkinsL. W.Neurochemical mechanisms of mild and moderate head injury: Implications for treatment. In LevinH. S.EisenbergH. M.BentonA. L. (Eds.), Mild head injury. New York: Oxford Univer. Press, 1989. Pp. 54–79.
6.
KrumholzA.SternB. J.Seizures following cardiopulmonary arrest. Epilepsia, 1984, 25, 670.
7.
MacLeanP. D.The triune brain in evolution. New York: Plenum, 1990.
8.
PerederyO.PersingerM. A.BlommeC.ParkerG.Absence of maternal behavior in rats with lithium/pilocarpine seizure-induced brain damage: Support of MacLean's triune brain theory. Physiology and Behavior, 1992, 52, 665–671.
