Nicotine may be the agent responsible for tobacco addiction. A noninvasive, easy measure for evaluating addiction is Fagerström's 1978 Tolerance Questionnaire. Present results are based on responses of 732 Spanish smokers to the Spanish version of the questionnaire. The questionnaire has a moderate reliability, and some items are more important than others. Among the Spanish smokers, the questionnaire differentiated the groups of 327 light, 275 normal, and 130 heavy smokers.
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