This paper is concerned with some experimental and clinical problems regarding the circadian chronobiology of epilepsy. Rhythmometrically analyzed, the temporal fluctuations of seizure susceptibility tend to indicate that epileptic events are circadian stage-dependent processes whose chronobiologic characteristics are possibly predictable on the basis of mathematical models. As an integrative discipline in physiology and psychology, behavioral chronobiology renders possible the discovery of new regulation processes concerning the central mechanisms of epilepsy. In this respect, the circadian psychophysiological patterns of epilepsy express dynamical biological systems which suggest some intermodulating endogenous processes between vigilance level and seizure susceptibility. Moreover, such chronobiologic studies applied to epileptic behavior suggest the development of new heuristic aspects in the field of comparative psychophysiology.
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References
1.
AutretA.GaillardPh.Sommeil et pathologie de l'encéphale (Rapport de neurologie). Paris: Masson, 1990.
2.
BeauM.Recherches statistiques pour servir à l'histoire de l'épilepsie et de l'hystérie. Archives Générales de Médecine, 1836, 11, 328–532.
3.
BessetA.Influence of generalized seizures on sleep organization. In StermanM. B.ShouseM. N.PassouantP. (Eds.), Sleep and epilepsy. New York: Academic Press, 1982. Pp. 339–346.
4.
BilliardM.Epilepsies and the sleep-wake cycle. In StermanM. B.ShouseM. N.PassouantP. (Eds.), Sleep and epilepsy. New York: Academic Press, 1982. Pp. 269–286.
5.
BinghamC.ArbogastB.Cornélissen-GuillaumeG.LeeJ. K.HalbergF.Inferential statistical methods for estimating and comparing cosinor parameters. Chronobiologia, 1982, 9, 397–439.
6.
BroughtonR. J.Biorhythmic variations in consciousness and psychological functions. Canadian Psychological Review, 1975, 16, 217–239.
7.
BroughtonR. J.Human consciousness and sleep/waking rhythms: A review and some neuropsychological considerations. Journal of Clinical Neuropsychology, 1982, 4, 193–218. (a).
8.
BroughtonR. J.Neurology and dreaming. Revue de Psychiatrie de l'Université d'Ottawa, 1982, 7, 101–110. (b).
9.
BroughtonR. J.The circasemidian sleep rhythm and its relationships to the circadian and ultradian sleep-wake rhythms. In KoellaW. P.ObâlF.SchulzH.VisserP. (Eds.), Sleep 86: The organization and regulation of sleep; various models. Stuttgart: Fischer-Verlag, 1988. Pp. 41–43.
10.
BernardinaDalla B.BondavalliS.ColamariaV.Benign epilepsy of childhood with rolandic spikes (BERS) during sleep. In StermanM. B.ShouseM. N.PassouantP. (Eds.), Sleep and epilepsy. New York: Academic Press, 1982. Pp. 495–506.
11.
Denny-BrownD.RobertsonE. G.Observations on records of local epileptic convulsions. Journal of Neurology and Psychopathology, 1934, 15, 97–136.
12.
FereC.De la fréquence des accès d'épilepsie selon les heures. Comptes Rendus de la Société de Biologie (Paris), 1888, 40, 740–742.
13.
FreudS.Dostojewski und die Vatertötung. Gesammelte Schriften, Vienna, 1928 [Cf., S. Freud. The ego and the id. New York: Norton, 1960 (Transl. by RiviereJ.)].
14.
FrommG. H.FaingoldC. L.BrowningR. A.BurnhamW. M. (Eds.) Epilepsy and the reticular formation. New York: Alan R. Liss, 1987.
15.
GastautH.Foreword. In FrommG. H.FaingoldC. L.BrowningR. A.BurnhamW. M. (Eds.), Epilepsy and the reticular formation. New York: Alan R. Liss, 1987. Pp. xi–xii.
16.
GlassL.MackeyM. C.From clocks to chaos. Princeton, NJ: Univer. of Princeton Press, 1988.
17.
GloohP.Generalized epilepsy with spike-and-wave discharge: A reinterpretation of electrographic and clinical manifestations. Epilepsia, 1979, 20, 571–588.
18.
GowersW. R.Epilepsy and other chronic convulsive diseases: Their causes, symptoms and treatment. London: William Wood, 1885.
19.
GriffithsG. M.FoxJ. T.Rhythm in epilepsy. Lancet, 1938, 2, 409–416.
20.
HalaszP.The generalized epileptic spike-wave mechanisms and the sleep-wakefulness system. Acta Physiologia Hungarian Academy of Sciences, 1972, 42, 293–314.
21.
HalbergF.Some current research methods and results with special reference to the central nervous system; Physiopathologic approach. American Journal of Mental Deficiency, 1960, 65, 156–171.
22.
HalbergF.Resolving power of electronic computers in chronopathology, and analogy to microscopy. Scientia, 1966, 101, 412–419.
23.
HalbergF.Chronobiology. Annual Review of Physiology, 1969, 31, 675–725.
24.
HalbergF.Quo Vadis basic and clinical chronobiology: Promise for health maintenance. American Journal of Anatomy, 1983, 168, 543–594.
25.
HalbergF.BittnerJ. J.GullyR. J.Twenty-four hour susceptibility to audiogenic convulsions in several stocks of mice. Federation Proceedings, 1955, 14, 67–68.
26.
HalbergF.CarandenteF.CornélissenG.KatinasG. S.Glossary of chronobiology. Chronobiologia, 1977, 4(Suppl. 1), 1–189.
27.
HalbergF.HowardR. B.24-hour periodicity and experimental medicine; examples and interpretations. Postgraduate Medicine, 1958, 24, 349–358.
28.
HallekM.ReinbergA.SchmidtR.LeviF.HellbrüggeT.Circadian and ultradian rhythms in behavior and seizures in children with petit mal epilepsy. Chronobiologia, 1983, 10, 131. (Abstract).
29.
HellbrüggeT.The development of circadian rhythms in infants. Cold Spring Harbor Symposium Quantitative Biology, 1960, 25, 311–323.
30.
HopkinsH.Time of appearance of epileptic seizures in relation to age, duration and type of syndrome. Journal of Nervous and Mental Diseases, 1933, 77, 153–162.
31.
JanzD.The Grand Mai epilepsies and the sleep-waking cycle. Epilepsia, 1962, 3, 69–109.
32.
JanzD.Epilepsy and the sleep/waking cycle. In VinkenP. J.BruynG. W. (Eds.), Handbook of clinical neurology. Vol. 15. The epilepsies. Amsterdam, The Netherlands: Elsevier, 1974. Pp. 457–490.
33.
JasperH.WardA.PopeA.Basic mechanisms of the epilepsies. London: Churchill, 1969.
34.
JinnaiD.MuxawaJ.Clinical observation in man: Forel-H-Tomy and its place in epilepsy. In FrommG. H.FaingoldC. L.BrowningR. A.BurnhamW. M. (Eds.), Epilepsy and the reticular formation. New York: Alan R. Liss, 1987. Pp. 163–191.
Langdon-DownM.BrainW. R.Time of day in relation to convulsions in epilepsy. Lancet, 1929, 1, 1029–1032.
37.
LockardJ. S.WardA. A. (Eds.) Épilepsy: A window to brain mechanisms. New York: Raven Press, 1980.
38.
LoiseauP.JallonP.Les épilepsies morphéiques de l'enfance. In KoellaW. P.LevinP. (Eds.), Sleep 1976. Basel: Karger, 1977. Pp. 43–49.
39.
LugaresiE.CirignottaF.Nocturnal paroxysmal dystonia. In StermanM. B.ShouseM. N.PassouamP. (Eds.), Sleep and epilepsy. New York: Academic Press, 1982. Pp. 507–511.
40.
EwertMeier K.BroughtonR. J.Photomyoclonic response of epileptic subjects during wakefulness, sleep, and arousal. Electroencephalography and Clinical Neurophysiology, 1967, 23, 142–151.
41.
MkolF.Monge-StraussM. F.Horaires des crises et répartition nycthémérale des activités EEG paroxystiques: étude chez 197 épileptiques. Revue Neurologique, 1987, 143, 451–456.
42.
MontplaisirJ.DemersL.Le somnambulisme. L'Union Médicale du Canada, 1983, 112, 619–623.
43.
MontplaisirJ.LaverdiereM.HilaireSaint J. M.Sleep and epilepsy. In GotmanJ.IvesJ. R.GloorP. (Eds.), Long-term monitoring and computer analysis of the EEG epilepsy. Amsterdam, The Netherlands: Elsevier, 1987. Pp. 1–48.
44.
MontplaisirJ.LaverdiereM.WalshJ.HilaireSaint J. M.BouvierG.Epilepsie et sommeil. L'Union Médicale du Canada, 1980, 109, 1004–1008.
45.
MoruzziG.L'Épilepsie expérimentale. (Transl. by M. Reuchlin)Paris: Hermann, 1950.
46.
NelsonW.TongY. L.LeeJ. K.HalbergF.Methods for cosinor-rhythmometry. Chronobiologia, 1979, 6, 305–323.
47.
OkumuraS. [Experimental study of the propagation of convulsive impulses.] Okayama Igakkai Zasshi, 1958, 70, 723–752. [Japanese].
48.
PassouantP.Influence des états de vigilance sur les épilepsies. In KoellaW. P.LevinP. (Eds.), Sleep 1976. Basel: Karger, 1977. Pp. 57–65.
49.
PatryF. L.The relation of time of day, sleep and other factors to the incidence of epileptic seizures. American Journal of Psychiatry, 1931, 87, 789–813.
50.
PenfieldW.Epilepsy, neurophysiology, and some brain mechanisms related to consciousness. In JasperH.WardA.PopeA. (Eds.), Basic mechanisms of the epilepsies. Boston, MA: Little Brown, 1969. Pp. 791–805.
51.
PenfieldW.JasperH.Epilepsy and the functional anatomy of the human brain. Boston, MA: Little, Brown, 1954.
52.
PenfieldW.RasmussenTh.The cerebral cortex of man. New York: Macmillan, 1950.
53.
PoirelC.Mise en évidence de variations nycthémérales de la susceptibilité à la crise audiogène chez la souris Swiss/Albinos. Comptes Rendus de la Société de Biologie (Paris), 1967, 161, 1461–1465.
54.
PoirelC.Some circadian rhythms in experimental ethology and comparative psychopathology. In SchevingL. E.HalbergF.PaulyJ. E. (Eds.), Chronobiology. Tokyo: Igaku Shoin, 1974. Pp. 540–543.
55.
PoirelC.Les rhythmes circadiens en psychopathologie. Paris: Masson, 1975.
56.
PoirelC.Circadian rhythms in behavior and experimental psychopathology. In BrownF. M.GraeberR. C. (Eds.), Rhythmic aspects of behavior. Hillsdale, NJ: Erlbaum, 1982. Pp. 363–398.
57.
PoirelC.Circadian rhythms and temporal structure of the susceptibility to tonic-clonic seizures in the mouse. Brain Research, 1984, 301, 384–388.
58.
PoirelC.Circadian patterns of vigilance and seizure susceptibility in genetically epileptic mice: Heuristic aspects in neurology. In PaulyJ. E.SchevingL. E. (Eds.), Advances in chronobiology. Vol. 2. New York: Alan R. Liss, 1987. Pp. 459–466.
59.
PoirelC.Rhythmometric analyses of circadian variations of grooming behavior in the mouse: Research perspectives in behavioral chronobiology. Journal of General Psychology, 1988, 115, 187–201.
60.
PoirelC.The concept of chronopsychology and the circadian rhythms in psychosomatic medicine. Revue de Médecine Psychosomatique, 1990, 31, 81–98.
61.
PoirelC.Circadian chronobiology of epilepsy: Murine models of seizure susceptibility and theoretical perspectives for neurology. Chronobiologia, 1990 (in press).
62.
PoirelC.DantzerR.Psychophysiological research on the circadian rhythms of epilepsy. La Presse Médicale, 1971, 79, 2175–2177.
63.
PoirelC.EnnajiM.Modèles chronobiologiques circadiens en neurologie comparée. Recherches complémentaires sur I'épilepsie expérimentale. In LégerJ. M. (Ed.), Comptes Rendus du Congrès de Psychiatrie et de Neurologie. Paris: Masson, 1990. Pp. 516–522.
64.
PoirelC.LaroucheB.Human circadian patterns of memory processes: Chronopsychology of rates of forgetting: A rhythmometric study. Psychological Reports, 1987, 61, 3–12.
65.
PoirelC.LaroucheB.Circadian patterns of basic emotional reactivity and stress related events revisited in mice treated with lithium: Behavioral rhythmometric analyses. Chronobiologia, 1989, 16, 229–239.
66.
SatoS.DreifussF.PerryJ. K.The effect of sleep on spike-wave discharges in absence seizures. Neurology, 1973, 23, 1335–1345.
67.
SechterD.PoirelC.Chronobiologie et psychiatrie. Paris: Masson, 1985.
68.
SilvaL. R.AmitaiY.ConnorsB. W.Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science, 1991, 251, 432–435.
69.
StermanM. B.ShouseM. N.PassouantP. (Eds.) Sleep and epilepsy. New York: Academic Press, 1982.
70.
TemkinO.The falling sickness, a history of epilepsy from the Greeks to the beginnings of modern neurology. Baltimore, MD: Johns Hopkins, 1971.
71.
TouchonJ.Effect of awakening on epileptic activity in primary generalized myoclonic epilepsy. In StermanM. B.ShouseM. N.PassouantP. (Eds.), Sleep and epilepsy. New York: Academic Press, 1982. Pp. 239–248.
72.
VizioliR.Le Syndrome de Lennox-Gastaut. Paris: Masson, 1970.
73.
WebbW. B.Foreword. In BrownF. M.GraeberR. C. (Eds.), Rhythmic aspects of behavior. Hillsdale, NJ: Erlbaum, 1982. Pp. ix–xiii.
74.
WebbW. B.Circadian biological rhythm aspects of sleep and epilepsy. In da SilvaMartins A. (Eds.), Biorhythms and epilepsy. New York: Raven Press, 1985. Pp. 13–27.
75.
WylerA. R.Epileptic neurons during sleep and wakefulness. Experimental Neurology, 1974, 42, 593–608.
76.
WylerA. R.WardA. A.Jr.Epileptic neurons. In LockardJ. S.WardA. A.Jr. (Eds.), Epilepsy, a window to brain mechanisms. New York: Raven Press, 1980. Pp. 51–68.
