43 female Sprague-Dawley rats were tested for emotionality using standard open-field procedures. The subjects were then injected with emulsified collagen-II. 31 responded with arthritic activity, clearly evidencing edema and erythema in from one to all 4 limbs. Duration of active response varied from 29 to 59 days. For the arthritic rats, severity of disease (combining duration and number of limbs by standard scores) correlated with both premorbid emotionality (where the partial r, controlling for preweight, was .47, with p < .01), and premorbid weight (where the partial r, controlling for pre-emotionality, was .38, with p < .05). The results encourage further study of premorbid behavioral tendencies as predictors of variations in arthritic responsivity.
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