This study measured depressive symptoms in 98 men of whom 49 had and 49 had not had a recent experience of family death or serious family illness. The relationships of depression and occurrence of the stressful event to immune function was explored. Persons with higher scores on depression in both groups showed less responsiveness of their lymphocytes to phytohemagglutinin and to allogeneic cells. Data indicate that not all persons react the same way to stressful events and that those with high and low depressive features can be differentiated by their immune responses.
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References
1.
BachF. H.HirschhornK.Lymphocyte interaction: A potential histocompatibility test in vitro. Science, 1964, 143, 813–814.
2.
BartropR. W.LuckhurstE.LazarusL.KilohL. G.Depressed lymphocyte function after bereavement. Lancet, 1977, 1, 834–836.
MaderazoE. G.WoronickC. L.A modified micropore filter assay of human granulocyte leukotaxis. In GallinJ. I. (Ed.), Leukocyte chemotaxis. New York: Raven Press, 1978. Pp. 43–55.
5.
PalmbladJ.CantellK.StranderH.Stressor exposure and immunological response in man: Interferon-producing capacity and phagocytosis. Journal of Psychosomatic Research, 1976, 20, 193–194.
6.
RogersM. P.DubeyD.ReichP.The influence of the psyche and the brain on immunity and disease susceptibility: A critical review. Psychosomatic Medicine, 1979, 41, 147–164.
7.
SteinM.SchiaviR. C.CamerinoM.Influence of brain and behavior on the immune system. Science, 1976, 191, 435–440.
