Oral morphine consumption of 10 catheterized rats and 10 non-operated controls was compared to test the hypothesis that stress associated with catheterization might increase opiate consumption by rats. No significant differences were found. An alternate interpretation of oral morphine consumption studies is suggested.
Get full access to this article
View all access options for this article.
References
1.
AlexanderB. K.CoambsR. B.HadawayP. F.The effects of housing and gender on morphine self-administration in rats. Psychopharmacology, 1978, 58, 175–179.
2.
ChipkinR. E.Aversiveness of oral methadone in rats. Unpublished Ph.D. dissertation, Medical College of Virginia., 1976.
3.
GoldsteinA.Heroin addiction and the role of methadone in its treatment. Archives of General Psychiatry, 1972, 26, 291–297.
4.
HadawayP. F.AlexanderB. K.CoambsR. B.BeyersteinB.The effect of housing and gender on preference for morphine-sucrose solutions in rats. Psychopharmacology, 1979, 66, 87–91.
5.
JaffeJ. H.Drug addiction and drug abuse. In GoodmanL. S.GilmanA. (Eds.), The pharmacological basis of therapeutics. (5th ed.) New York: Macmillan, 1975. Pp. 284–324.
