Recent observations suggest that psychotherapy can influence biochemical and physiologic parameters which determine drug disposition and response to drugs. Consequently, clinical psychologists can participate in and share responsibility for the outcome of pharmacotherapy. Current interpretations of psychiatric concepts in biochemical and neurologic terms, and in particular, data on the asymmetry of hemispheric function in normal individuals and the mentally ill, now offer fresh opportunities to identify structural and neurochemical brain targets for psychotherapy which can be coupled with the sciences of drug distribution and neurochemical mechanisms of drug action. Several examples are presented to illustrate opportunities to achieve more desirable drug disposition and action by psychotherapeutic techniques. The objective of this report is to alert clinical psychologists, psychiatrists and drug therapists to the potential of this coordinated approach to treatment.
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