5-dimethyldithiocarbamylpicolinic acid (YP-279) is a selective inhibitor of peripheral dopamine β-hydroxylase (DβH). After 72 training days in a discriminated Sidman avoidance situation, rats were administered three dosages (25, 50, and 75 mg/kg) of YP-279. YP-279 treatment produced no observable change in avoidance responses. These results indicate that well-learned coping behavior was not influenced by the inhibition of peripheral DβH.
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