Caerulein, a decapeptide extracted from the skin of frogs, has been shown to mimic the meal-limiting actions of cholecystokinin. Caerulein was administered systemically (.25, .50, .75 μg/kg) and intraventricularly (.05, .10, .25 μg/kg) to estradiol (5 μg) and oil-primed ovariectomized rats. Estradiol pretreatment did not enhance the meal-restricting effects of caerulein nor did it increase the binding of tritiated caerulein by the ventromedial hypothalamus. It was concluded that gut hormones do not underlie estradiol's effect on size of meal.
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