Abstract
A model is presented to explain one of the possible functions of the Cajal-Retzius cells which are known to mature perinatally but not to survive into late infantile life. In this model the processes of the Cajal-Retzius (C. R.) cells and the ventricular surface act as a transient capacitor-like mechanism during neural migration. Neurons which are connected to the ventricular surface during migration by an end foot are consequently guided by the Cajal-Retzius cell processes located in the upper strata of the cortical molecular layer. Once the end foot is severed migration stops and differentiation begins. When the period of migration nears completion postnatally, the mechanism is destroyed as these cells die or lose their connection with the cortical pial surface. Calculations are given to support the feasibility of this model.
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