Exposure of rats to a novel substance (.1% sodium saccharin) was paired with 0, .25, .5, 1.0, 2.0, and 4.0 mg/kg of Δ9-THC (tetrahydrocannabinol) for 1, 6 or 12 days. In a subsequent test, all groups showed a decreased preference for saccharin as the dosage of THC was increased. The results indicated that THC is aversive in multiple as well as single injections.
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References
1.
CorcoranM. E.Role of drug novelty and metabolism in the aversive effects of hashish injections in tats. Life Sciences, 1973, 12, 63–72.
2.
ElsmoreT. F.FletcherG. V.Δ9-tetrahydrocannabinol: Aversive effects in rats at high doses. Science, 1972, 175, 911–912.
3.
WeilA. T.ZinbergW. E.NelsonJ. M.Clinical and psychological effects of marijuana in man. Science, 1968, 162, 1234–1242.
4.
WinerB. J.Statistical principles in experimental design. New York: McGraw-Hill, 1962.
