Effect of Securigera Securidaca Linnaeus on Conditioned Avoidance in Mice

Abstract

6 groups of albino mice (ns = 6) were administered finely crushed Securigera Securidaca or its extracts. 3 groups of animals were given chloroform, absolute ether, or petroleum ether extract of seeds of Securigera Securidaca. The dose for each extract was 100 mg/kg body weight. Two groups of animals were given 100 mg/kg or 250 mg/kg body weight of crushed seeds. The control group of animals was given olive oil 10 cc/kg body weight. All the doses of the drugs were given orally. The conditioned avoidance technique was used 2 and 4 hr. after every treatment to test Ss' learning. Analysis of variance showed significant differences for treatments, days of treatments, and animals within time and treatment. Also a significant time-day interaction indicated the differential effect of time on different days.